Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50003545
Substrate
n/a
Meas. Tech.
ChEBML_154975
IC50
1900±n/a nM
Citation
 Carceller, E; Almansa, C; Merlos, M; Giral, M; Bartrolí, J; García-Rafanell, J; Forn, J (Pyridylcyanomethyl)piperazines as orally active PAF antagonists. J Med Chem 35:4118-34 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50003545
Synonyms:
3,3-Diphenyl-1-[4-(pyridine-4-carbonyl)-piperazin-1-yl]-propan-1-one; hydrochloride; hydrate | CHEMBL553152
Type:
Small organic molecule
Emp. Form.:
C25H25N3O2
Mol. Mass.:
399.4849
SMILES:
O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(=O)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: