Reaction Details Report a problem with these data
Target
Neuromedin-K receptor
Ligand
BDBM50001593
Substrate
n/a
Meas. Tech.
ChEBML_209701
EC50
1177±n/a nM
Citation
 Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; McElroy, AB; Porter, B; Ross, BC; Stephens-Smith, M; Ward, P Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem 35:4195-204 (1992) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_RAT | Neurokinin 3 receptor | Tac3r | Tacr3
Type:
n/a
Mol. Mass.:
51128.60
Organism:
Rattus norvegicus
Description:
ChEMBL_10983
Residue:
452
Sequence:
MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM50001593
Synonyms:
CHEMBL131872 | N-{1-[1-(1-{1-[1-(1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butyl]-2-oxo-pyrrolidin-3-ylcarbamoyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-hydroxy-ethyl}-3-(2,6-diamino-hexanoylamino)-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C42H68N10O11S
Mol. Mass.:
921.115
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O
Structure:
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