Target
Sterol O-acyltransferase 1
Ligand
BDBM50003830
Substrate
n/a
Meas. Tech.
ChEBML_28352
IC50
110±n/a nM
Citation
 Harris, NVSmith, CAshton, MJBridge, AWBush, RCCoffee, ECDron, DIHarper, MFLythgoe, DJNewton, CG Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 35:4384-92 (1992) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50003830
Synonyms:
6-[4,5-Bis-(3-chloro-phenyl)-1H-imidazol-2-ylsulfanylmethyl]-4-hydroxy-4-methyl-tetrahydro-pyran-2-one | CHEMBL336696
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2N2O3S
Mol. Mass.:
463.377
SMILES:
C[C@]1(O)CC(CSc2nc(c([nH]2)-c2cccc(Cl)c2)-c2cccc(Cl)c2)OC(=O)C1
Structure:
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