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Target
Sterol O-acyltransferase 1
Ligand
BDBM50003837
Substrate
n/a
Meas. Tech.
ChEBML_28352
IC50
280±n/a nM
Citation
 Harris, NV; Smith, C; Ashton, MJ; Bridge, AW; Bush, RC; Coffee, EC; Dron, DI; Harper, MF; Lythgoe, DJ; Newton, CG Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 35:4384-92 (1992) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50003837
Synonyms:
6-(4,5-Di-p-tolyl-1H-imidazol-2-ylsulfanylmethyl)-4-methyl-5,6-dihydro-pyran-2-one | CHEMBL136540
Type:
Small organic molecule
Emp. Form.:
C24H24N2O2S
Mol. Mass.:
404.525
SMILES:
CC1=CC(=O)OC(CSc2nc(c([nH]2)-c2ccc(C)cc2)-c2ccc(C)cc2)C1 |t:1|
Structure:
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