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TargetLeukocyte elastase
LigandBDBM50005165
Substrate/Competitorn/a
Meas. Tech.ChEBML_63659
IC50>5000±n/a nM
Citation Skiles, JWFuchs, VMiao, CSorcek, RGrozinger, KGMauldin, SCVitous, JMui, PWJacober, SChow, G Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. J Med Chem35:641-62 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50005165
NameBDBM50005165
Synonyms:CHEMBL345792 | [1-(Indan-2-yl-{[2-methyl-1-(4-trifluoromethyl-benzoyl)-propylcarbamoyl]-methyl}-carbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C36H40F3N3O5
Mol. Mass.651.7151
SMILESCC(C)C(NC(=O)OCc1ccccc1)C(=O)N(CC(=O)N[C@@H](C(C)C)C(=O)c1ccc(cc1)C(F)(F)F)C1Cc2ccccc2C1
Structure
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