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Target
Neutrophil elastase
Ligand
BDBM50005170
Substrate
n/a
Meas. Tech.
ChEBML_63659
IC50
452±n/a nM
Citation
 Skiles, JW; Fuchs, V; Miao, C; Sorcek, R; Grozinger, KG; Mauldin, SC; Vitous, J; Mui, PW; Jacober, S; Chow, G Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. J Med Chem 35:641-62 (1992) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50005170
Synonyms:
CHEMBL158647 | N-{4-[(1-{Indan-2-yl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-methoxyimino-methyl]-thiazol-2-yl}-succinamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C34H43F3N6O8S
Mol. Mass.:
752.801
SMILES:
CCOC(=O)CCC(=O)Nc1nc(cs1)C(=N/OC)\C(=O)NC(C(C)C)C(=O)N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1Cc2ccccc2C1
Structure:
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