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TargetHypoxia-inducible factor prolyl hydroxylase 4 (HIF)
LigandBDBM50368561
Substrate/Competitorn/a
Meas. Tech.ChEBML_157456
IC50 2400±n/a nM
Citation Dowell, RIHadley, EM Novel inhibitors of prolyl 4-hydroxylase. J Med Chem35:800-4 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxia-inducible factor prolyl hydroxylase 4 (HIF)
Name:Hypoxia-inducible factor prolyl hydroxylase
Synonyms:Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Transmembrane prolyl 4-hydroxylase
Type:Enzyme
Mol. Mass.:56654.25
Organism:Homo sapiens (Human)
Description:Q9NXG6
Residue:502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50368561
NameBDBM50368561
Synonyms:CHEMBL1744251
TypeSmall organic molecule
Emp. Form.C11H5ClN2O5S2
Mol. Mass.344.752
SMILES[O-]C(=O)c1ccc(cn1)C(=O)[N-]S(=O)(=O)c1ccc(Cl)s1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a