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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50453287
Substrate/Competitorn/a
Meas. Tech.ChEBML_62421
Ki>1000±n/a nM
Citation Moon, MWMorris, JKHeier, RFChidester, CGHoffmann, WEPiercey, MFAlthaus, JSVon Voigtlander, PFEvans, DLFigur, LM Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds. J Med Chem35:1076-92 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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BDBM50453287
NameBDBM50453287
Synonyms:CHEMBL2092845
TypeSmall organic molecule
Emp. Form.C16H24ClN3O
Mol. Mass.309.834
SMILESCl.CCCN(CCC)[C@H]1Cc2cccc3nc(O)n(C1)c23 |r|
Structure
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