Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50005689
Substrate
n/a
Meas. Tech.
ChEMBL_159480 (CHEMBL769440)
IC50
20±n/a nM
Citation
 Tam, TFCarrière, JMacDonald, DCastelhano, ALPliura, DHDewdney, NJThomas, EMBach, CBarnett, JChan, H Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides. J Med Chem 35:1318-20 (1992) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50005689
Synonyms:
BDBM50456284 | CHEMBL3085515 | {1-[1-Benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2,3-dioxo-propylcarbamoyl]-2-carbamoyl-ethyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C31H39N5O7
Mol. Mass.:
593.6707
SMILES:
CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: