Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50368601
Substrate
n/a
Meas. Tech.
ChEMBL_159483 (CHEMBL769443)
IC50
3.1±n/a nM
Citation
 Tam, TF; Carrière, J; MacDonald, D; Castelhano, AL; Pliura, DH; Dewdney, NJ; Thomas, EM; Bach, C; Barnett, J; Chan, H Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides. J Med Chem 35:1318-20 (1992) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50368601
Synonyms:
CHEMBL1794048 | CHEMBL3349509
Type:
Small organic molecule
Emp. Form.:
C39H54N6O10
Mol. Mass.:
766.8803
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(N)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OC
Structure:
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