Reaction Details
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Report a problem with these dataTarget
Cholecystokinin receptor type A
Ligand
BDBM50005822
Substrate
n/a
Meas. Tech.
ChEBML_50060
IC50
123±n/a nM
Citation
Fincham, CI; Higginbottom, M; Hill, DR; Horwell, DC; O'Toole, JC; Ratcliffe, GS; Rees, DC; Roberts, E Amide bond replacements incorporated into CCK-B selective"dipeptoids". J Med Chem 35:1472-84 (1992) [PubMed] Article More Info.:
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
Inhibitor
Name:
BDBM50005822
Synonyms:
CHEMBL36443 | [2-(1H-Indol-3-yl)-1-methyl-1-(methyl-phenethyl-carbamoyl)-ethyl]-carbamic acid adamantan-2-yl ester
Type:
Small organic molecule
Emp. Form.:
C32H39N3O3
Mol. Mass.:
513.6704
SMILES:
CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 |wU:33.41,35.39,29.32,wD:31.33,TLB:27:28:34:31.36.32,THB:30:29:34:31.36.32,30:31:34:28.29.37,32:31:28:33.34.37,(14.82,-9.82,;15.49,-8.41,;17.01,-8.32,;17.88,-9.59,;19.26,-8.86,;20.54,-9.7,;21.92,-8.99,;21.98,-7.45,;20.67,-6.62,;19.31,-7.35,;14.63,-7.15,;15.3,-5.77,;13.1,-7.26,;13.87,-8.6,;11.85,-6.36,;12.01,-4.82,;10.85,-3.82,;11.48,-2.41,;13,-2.54,;14.15,-1.52,;15.6,-1.97,;15.94,-3.5,;14.8,-4.53,;13.34,-4.05,;12.33,-8.6,;10.79,-8.58,;10.04,-7.23,;10.01,-9.89,;8.47,-9.86,;8.47,-11.39,;7.44,-12.65,;6.04,-12.09,;4.53,-12.51,;5.74,-11.24,;5.72,-9.76,;7.07,-9.28,;6.03,-10.5,;7.06,-11.72,)|
Structure:
