Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50005978
Substrate
n/a
Meas. Tech.
ChEBML_28339
IC50
3000±n/a nM
Citation
 Roth, BD; Blankley, CJ; Hoefle, ML; Holmes, A; Roark, WH; Trivedi, BK; Essenburg, AD; Kieft, KA; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35:1609-17 (1992) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50005978
Synonyms:
(2-Methyl-4-octadec-9-enoylamino-phenyl)-acetic acid ethyl ester | CHEMBL40767
Type:
Small organic molecule
Emp. Form.:
C29H47NO3
Mol. Mass.:
457.6884
SMILES:
CCCCCCCC\C=C\CCCCCCCC(=O)Nc1ccc(CC(=O)OCC)c(C)c1
Structure:
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