Reaction Details Report a problem with these data
Target
Endothelin-converting enzyme 1
Ligand
BDBM50046138
Substrate
n/a
Meas. Tech.
ChEBML_64345
IC50
4800±n/a nM
Citation
Bertenshaw, SR; Rogers, RS; Stern, MK; Norman, BH; Moore, WM; Jerome, GM; Branson, LM; McDonald, JF; McMahon, EG; Palomo, MA Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency. J Med Chem 36:173-6 (1993) [PubMed] Article
More Info.:
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1)
Type:
Enzyme
Mol. Mass.:
87155.11
Organism:
Homo sapiens (Human)
Description:
P42892
Residue:
770
Sequence:
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Inhibitor
Name:
BDBM50046138
Synonyms:
2-[2-(Cyclohexylmethyl-hydroxy-phosphorylamino)-4-methyl-pentanoylamino]-3-(1H-indol-3-yl)-propionic acid
Type:
Small organic molecule
Emp. Form.:
C24H35N3O5P
Mol. Mass.:
476.5261
SMILES:
CC(C)C[C@H](NP([O-])(=O)CC1CCCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O