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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50041469
Substrate
n/a
Meas. Tech.
ChEMBL_1137 (CHEMBL616082)
Ki
0.300000±n/a nM
Citation
 Zhuang, ZP; Kung, MP; Kung, HF Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J Med Chem 36:3161-5 (1993) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50041469
Synonyms:
(R,S) 7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol | 7-[((E)-3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol | CHEMBL284716
Type:
Small organic molecule
Emp. Form.:
C16H22INO
Mol. Mass.:
371.2565
SMILES:
CCCN(C\C=C\I)C1CCc2cccc(O)c2C1
Structure:
Search PDB for entries with ligand similarity: