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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50042730
Substrate/Competitorn/a
Meas. Tech.ChEBML_62882
Ki 0.020000±n/a nM
Citation Mach, RHLuedtke, RRUnsworth, CDBoundy, VANowak, PAScripko, JGElder, STJackson, JRHoffman, PLEvora, PH 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. J Med Chem36:3707-20 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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  Blast E-value cutoff:
BDBM50042730
NameBDBM50042730
Synonyms:4-Amino-5-chloro-N-[5-(4-fluoro-benzyl)-octahydro-quinolizin-2-yl]-2-methoxy-benzamide | CHEMBL2112608
TypeSmall organic molecule
Emp. Form.C24H28BrFN2O3
Mol. Mass.491.393
SMILESCOc1cc(Br)cc(C(=O)NC2CC3CCCC(C2)N3Cc2ccc(F)cc2)c1OC |TLB:20:19:14.15.16:18.11.12,THB:10:11:14.15.16:19|
Structure
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