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TargetSerotonin (5-HT) receptor
LigandBDBM50368853
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1101
Ki 3.6±n/a nM
Citation Meyer, MDDeBernardis, JFHancock, AA Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes. J Med Chem37:105-12 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin (5-HT) receptor
Name:Serotonin 1 (5-HT1) receptor
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5HT1A) | G-21 | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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  Blast E-value cutoff:
BDBM50368853
NameBDBM50368853
Synonyms:CHEMBL1743629
TypeSmall organic molecule
Emp. Form.C29H34N2O3
Mol. Mass.458.5919
SMILESCOc1cccc2CC3CN(CCCCN4C(=O)C5C(C6C=CC5C5C=CC65)C4=O)CCC3c12 |c:21,26,(-.49,-9.82,;.85,-9.05,;.84,-7.51,;-.49,-6.74,;-.49,-5.2,;.84,-4.42,;2.18,-5.19,;3.64,-4.7,;4.56,-5.95,;6.08,-6.1,;6.71,-7.5,;8.25,-7.66,;8.88,-9.06,;10.41,-9.23,;11.04,-10.63,;12.57,-10.78,;13.83,-9.88,;13.83,-8.34,;15.06,-10.79,;14.57,-12.25,;15.59,-13.39,;16.79,-12.34,;15.46,-11.57,;16.56,-10.49,;17.57,-11.63,;19.03,-12.12,;18.54,-13.57,;17.09,-13.08,;13.03,-12.25,;12.14,-13.5,;5.81,-8.75,;4.28,-8.6,;3.65,-7.2,;2.18,-6.73,)|
Structure
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