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Target
Delta-type opioid receptor
Ligand
BDBM50041669
Substrate
n/a
Meas. Tech.
ChEMBL_146764 (CHEMBL755208)
IC50
18±n/a nM
Citation
 Haaseth, RC; Horan, PJ; Bilsky, EJ; Davis, P; Zalewska, T; Slaninova, J; Yamamura, HI; Weber, SJ; Davis, TP; Porreca, F [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. J Med Chem 37:1572-7 (1994) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50041669
Synonyms:
2-Amino-N-(7-benzyl-4-dihydroxymethyl-3,3,10,14,14-pentamethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradec-13-yl)-3-(4-hydroxy-phenyl)-propionamide | CHEMBL43637
Type:
Small organic molecule
Emp. Form.:
C31H43N5O7S2
Mol. Mass.:
661.832
SMILES:
CC1NC(=O)C(NC(=O)C(N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)C(NC(=O)C(Cc2ccccc2)NC1=O)C(O)O
Structure:
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