Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50000084
Substrate
n/a
Meas. Tech.
ChEMBL_200977 (CHEMBL802064)
Ki
390±n/a nM
Citation
 de Costa, BR; He, XS; Dominguez, C; Cutts, J; Williams, W; Bowen, WD A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes. J Med Chem 37:314-21 (1994) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50000084
Synonyms:
CHEMBL325320 | N*1*-[2-(3,4-Dichloro-phenyl)-ethyl]-ethane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C10H14Cl2N2
Mol. Mass.:
233.138
SMILES:
NCCNCCc1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: