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Target
Renin
Ligand
BDBM50040395
Substrate
n/a
Meas. Tech.
ChEMBL_195938 (CHEMBL801664)
IC50
25±n/a nM
Citation
 Raddatz, P; Minck, KO; Rippmann, F; Schmitges, CJ Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements. J Med Chem 37:486-97 (1994) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50040395
Synonyms:
(3-Phenyl-propyl)-phosphonic acid mono-[(S)-1-((1S,2R)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-pentyl] ester | CHEMBL144349
Type:
Small organic molecule
Emp. Form.:
C29H50NO6P
Mol. Mass.:
539.6842
SMILES:
CCCC[C@H](OP(O)(=O)CCCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(O)CC(C)C
Structure:
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