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Target
Glyceraldehyde-3-phosphate dehydrogenase
Ligand
BDBM50030966
Substrate
n/a
Meas. Tech.
ChEMBL_72903 (CHEMBL684097)
IC50
>10000000±n/a nM
Citation
 Van Calenbergh, S; Verlinde, CL; Soenens, J; De Bruyn, A; Callens, M; Blaton, NM; Peeters, OM; Rozenski, J; Hol, WG; Herdewijn, P Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. J Med Chem 38:3838-49 (1995) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase
Synonyms:
G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver | glyceraldehyde-3-phosphate dehydrogenase
Type:
PROTEIN
Mol. Mass.:
36060.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511315
Residue:
335
Sequence:
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
  
Inhibitor
Name:
BDBM50030966
Synonyms:
CHEMBL125025 | N-[2-(6-Amino-2-methyl-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl]-3-methoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C19H22N6O5
Mol. Mass.:
414.4152
SMILES:
COc1cccc(c1)C(=O)NC1C(O)C(CO)OC1n1cnc2c(N)nc(C)nc12
Structure:
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