Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50048232
Substrate
n/a
Meas. Tech.
ChEMBL_61949 (CHEMBL671349)
Ki
420±n/a nM
Citation
 Thurkauf, A; Yuan, J; Chen, X; Wasley, JW; Meade, R; Woodruff, KH; Huston, K; Ross, PC 1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding. J Med Chem 38:4950-2 (1996) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_CHLAE
Type:
PROTEIN
Mol. Mass.:
44355.59
Organism:
Chlorocebus aethiops
Description:
ChEMBL_105569
Residue:
400
Sequence:
MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50048232
Synonyms:
1-(1-Phenyl-1H-pyrrol-3-ylmethyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol | CHEMBL446892
Type:
Small organic molecule
Emp. Form.:
C23H23F3N2O
Mol. Mass.:
400.4367
SMILES:
OC1(CCN(Cc2ccn(c2)-c2ccccc2)CC1)c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: