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Target
Thyroid hormone receptor beta
Ligand
BDBM18865
Substrate
n/a
Meas. Tech.
ChEMBL_143915 (CHEMBL752718)
IC50
0.110000±n/a nM
Citation
 Yokoyama, N; Walker, GN; Main, AJ; Stanton, JL; Morrissey, MM; Boehm, C; Engle, A; Neubert, AD; Wasvary, JM; Stephan, ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem 38:695-707 (1995) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52661.52
Organism:
RAT
Description:
thyroid beta 0 RAT::P18113
Residue:
461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM18865
Synonyms:
3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}propanoic acid | CHEMBL289343 | dibromo phenylpropionic acid, 6
Type:
Small organic molecule
Emp. Form.:
C18H18Br2O4
Mol. Mass.:
458.141
SMILES:
CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)ccc1O
Structure:
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