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Target
Thyroid hormone receptor beta
Ligand
BDBM50036424
Substrate
n/a
Meas. Tech.
ChEMBL_143914 (CHEMBL872845)
IC50
0.37±n/a nM
Citation
 Yokoyama, N; Walker, GN; Main, AJ; Stanton, JL; Morrissey, MM; Boehm, C; Engle, A; Neubert, AD; Wasvary, JM; Stephan, ZF Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J Med Chem 38:695-707 (1995) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
Erba2 | Nr1a2 | THB_RAT | Thrb | Thyroid Hormone Receptor (TR-beta) | Thyroid hormone receptor beta | Thyroid hormone receptor beta-1 | thyroid beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52661.52
Organism:
RAT
Description:
thyroid beta 0 RAT::P18113
Residue:
461
Sequence:
MTPNSMTENRLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50036424
Synonyms:
CHEMBL159334 | N-{3,5-Dichloro-4-[3-(4-fluoro-benzoyl)-4-hydroxy-phenoxy]-phenyl}-oxalamic acid
Type:
Small organic molecule
Emp. Form.:
C21H12Cl2FNO6
Mol. Mass.:
464.227
SMILES:
OC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(c2)C(=O)c2ccc(F)cc2)c(Cl)c1
Structure:
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