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Target
D(2) dopamine receptor
Ligand
BDBM50053746
Substrate
n/a
Meas. Tech.
ChEMBL_58683 (CHEMBL670247)
IC50
286±n/a nM
Citation
 Hrib, NJ; Jurcak, JG; Bregna, DE; Burgher, KL; Hartman, HB; Kafka, S; Kerman, LL; Kongsamut, S; Roehr, JE; Szewczak, MR; Woods-Kettelberger, AT; Corbett, R Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate. J Med Chem 39:4044-57 (1996) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50053746
Synonyms:
3-{4-[4-(6-Chloro-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-butyl}-2,5,5-trimethyl-thiazolidin-4-one | CHEMBL133671
Type:
Small organic molecule
Emp. Form.:
C21H29ClN4OS2
Mol. Mass.:
453.064
SMILES:
CC1SC(C)(C)C(=O)N1CCCCN1CCN(CC1)c1nsc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: