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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50054326
Substrate
n/a
Meas. Tech.
ChEMBL_32263 (CHEMBL645597)
IC50
7560±n/a nM
Citation
 Costantino, L; Rastelli, G; Vescovini, K; Cignarella, G; Vianello, P; Del Corso, A; Cappiello, M; Mura, U; Barlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem 39:4396-405 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50054326
Synonyms:
4-(8,9-Dimethoxy-3-oxo-5,6-dihydro-3H-benzo[h]cinnolin-2-yl)-butyric acid | CHEMBL139073
Type:
Small organic molecule
Emp. Form.:
C18H20N2O5
Mol. Mass.:
344.3618
SMILES:
COc1cc2CCc3cc(=O)n(CCCC(O)=O)nc3-c2cc1OC
Structure:
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