Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50054320
Substrate
n/a
Meas. Tech.
ChEMBL_32263 (CHEMBL645597)
IC50
12600±n/a nM
Citation
 Costantino, LRastelli, GVescovini, KCignarella, GVianello, PDel Corso, ACappiello, MMura, UBarlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem 39:4396-405 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50054320
Synonyms:
(3-Oxo-5,6-dihydro-3H-benzo[h]cinnolin-2-yl)-acetic acid | CHEMBL54222
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3
Mol. Mass.:
256.2567
SMILES:
OC(=O)Cn1nc-2c(CCc3ccccc-23)cc1=O
Structure:
Search PDB for entries with ligand similarity: