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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50054329
Substrate
n/a
Meas. Tech.
ChEMBL_32263 (CHEMBL645597)
IC50
33000±n/a nM
Citation
 Costantino, L; Rastelli, G; Vescovini, K; Cignarella, G; Vianello, P; Del Corso, A; Cappiello, M; Mura, U; Barlocco, D Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors. J Med Chem 39:4396-405 (1996) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50054329
Synonyms:
2-Carboxymethyl-3-oxo-2,3,5,6-tetrahydro-benzo[h]cinnoline-4-carboxylic acid | CHEMBL336465
Type:
Small organic molecule
Emp. Form.:
C15H12N2O5
Mol. Mass.:
300.2662
SMILES:
OC(=O)Cn1nc-2c(CCc3ccccc-23)c(C(O)=O)c1=O
Structure:
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