Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50054681
Substrate
n/a
Meas. Tech.
ChEMBL_31254 (CHEMBL640399)
Ki
4470±n/a nM
Citation
 Jiang, JL; van Rhee, AM; Melman, N; Ji, XD; Jacobson, KA 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 39:4667-75 (1996) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50054681
Synonyms:
2,4-Dimethyl-6-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester | CHEMBL325983 | diethyl 2,4-dimethyl-6-phenylpyridine-3,5-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C19H21NO4
Mol. Mass.:
327.3743
SMILES:
CCOC(=O)c1c(C)nc(-c2ccccc2)c(C(=O)OCC)c1C
Structure:
Search PDB for entries with ligand similarity: