Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50064533
Substrate
n/a
Meas. Tech.
ChEMBL_1159 (CHEMBL616104)
Ki
2.5±n/a nM
Citation
 Reitz, ABBaxter, EWCodd, EEDavis, CBJordan, ADMaryanoff, BEMaryanoff, CAMcDonnell, MEPowell, ETRenzi, MJSchott, MRScott, MKShank, RPVaught, JL Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem 41:1997-2009 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50064533
Synonyms:
2-{4-[3-(Piperidine-1-carbonyl)-benzyl]-piperazin-1-yl}-benzonitrile | CHEMBL62024
Type:
Small organic molecule
Emp. Form.:
C24H28N4O
Mol. Mass.:
388.5053
SMILES:
O=C(N1CCCCC1)c1cccc(CN2CCN(CC2)c2ccccc2C#N)c1
Structure:
Search PDB for entries with ligand similarity: