Target
Endothelin-1 receptor
Ligand
BDBM50065511
Substrate
n/a
Meas. Tech.
ChEMBL_63353 (CHEMBL679118)
IC50
113±n/a nM
Citation
 Astles, PCBrealey, CBrown, TJFacchini, VHandscombe, CHarris, NVMcCarthy, CMcLay, IMPorter, BRoach, AGSargent, CSmith, CWalsh, RJ Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives. J Med Chem 41:2732-44 (1998) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50065511
Synonyms:
(S)-4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-tolyl-butyric acid | CHEMBL94141
Type:
Small organic molecule
Emp. Form.:
C23H21NO4S
Mol. Mass.:
407.482
SMILES:
Cc1ccccc1[C@H](CCC(O)=O)Oc1cc(OCc2ccsc2)ccc1C#N
Structure:
Search PDB for entries with ligand similarity: