Target
Endothelin receptor type B
Ligand
BDBM50065522
Substrate
n/a
Meas. Tech.
ChEMBL_64042 (CHEMBL873580)
IC50
10000±n/a nM
Citation
 Astles, PCBrealey, CBrown, TJFacchini, VHandscombe, CHarris, NVMcCarthy, CMcLay, IMPorter, BRoach, AGSargent, CSmith, CWalsh, RJ Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives. J Med Chem 41:2732-44 (1998) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49483.43
Organism:
RAT
Description:
ENDOTHELIN B EDNRB RAT::P21451
Residue:
442
Sequence:
MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50065522
Synonyms:
(R)-4-[5-(Benzo[1,3]dioxol-5-ylmethoxy)-2-cyano-phenoxy]-4-o-tolyl-butyric acid | CHEMBL93097
Type:
Small organic molecule
Emp. Form.:
C26H23NO6
Mol. Mass.:
445.4639
SMILES:
Cc1ccccc1[C@@H](CCC(O)=O)Oc1cc(OCc2ccc3OCOc3c2)ccc1C#N
Structure:
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