Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50066342
Substrate
n/a
Meas. Tech.
ChEMBL_156025 (CHEMBL763678)
IC50
1700±n/a nM
Citation
 De Rosa, M; Giordano, S; Scettri, A; Sodano, G; Soriente, A; Pastor, PG; Alcaraz, MJ; Payá, M Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues. J Med Chem 41:3232-8 (1998) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Allergen Api m I | Allergen=Api m 1 | PA2_APIME | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 (Bee)
Type:
PROTEIN
Mol. Mass.:
19061.47
Organism:
Apis mellifera
Description:
ChEMBL_1277435
Residue:
167
Sequence:
MQVVLGSLFLLLLSTSHGWQIRDRIGDNELEERIIYPGTLWCGHGNKSSGPNELGRFKHTDACCRTHDMCPDVMSAGESKHGLTNTASHTRLSCDCDDKFYDCLKNSADTISSYFVGKMYFNLIDTKCYKLEHPVTGCGERTEGRCLHYTVDKSKPKVYQWFDLRKY
  
Inhibitor
Name:
BDBM50066342
Synonyms:
5-Hydroxy-4-[5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-3,6-dihydro-2H-pyran-2-yl]-5H-furan-2-one | CHEMBL109301
Type:
Small organic molecule
Emp. Form.:
C24H34O4
Mol. Mass.:
386.5244
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-1=[#6]-[#6]-[#6](-[#8]-[#6]-1)-[#6]-1=[#6]-[#6](=O)-[#8]-[#6]-1-[#8] |t:15,22|
Structure:
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