Target
Endothelin-1 receptor
Ligand
BDBM50068682
Substrate
n/a
Meas. Tech.
ChEMBL_63369 (CHEMBL676105)
Ki
54±n/a nM
Citation
 Murugesan, NGu, ZStein, PDBisaha, SSpergel, SGirotra, RLee, VGLloyd, JMisra, RNSchmidt, JMathur, AStratton, LKelly, YFBird, EWaldron, TLiu, ECZhang, RLee, HSerafino, RAbboa-Offei, BMathers, PGiancarli, MSeymour, AAWebb, MLHunt, JT Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). J Med Chem 41:5198-218 (1999) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50068682
Synonyms:
4'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | CHEMBL356901
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3S
Mol. Mass.:
371.453
SMILES:
CN(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Structure:
Search PDB for entries with ligand similarity: