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Target
Kappa-type opioid receptor
Ligand
BDBM50271816
Substrate
n/a
Meas. Tech.
ChEMBL_145851 (CHEMBL756114)
IC50
185±n/a nM
Citation
 Houghten, RA; Pinilla, C; Appel, JR; Blondelle, SE; Dooley, CT; Eichler, J; Nefzi, A; Ostresh, JM Mixture-based synthetic combinatorial libraries. J Med Chem 42:3743-78 (1999) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50271816
Synonyms:
(3S,6S)-7-(2-Bicyclo[2.2.1]hept-2-yl-ethyl)-6-(4-methoxy-benzyl)-3-methyl-2,5,6,7-tetrahydro-3H-imidazo[1,2-a]imidazol-1-ium
Type:
Small organic molecule
Emp. Form.:
C23H34N3O
Mol. Mass.:
368.535
SMILES:
COc1ccc(C[C@H]2CN3[C@@H](C)C[NH+]=C3N2CCC2CC3CCC2C3)cc1 |r,c:13,THB:17:18:24:22.21|
Structure:
Search PDB for entries with ligand similarity: