Reaction Details Report a problem with these data
Target
Neprilysin
Ligand
BDBM50083382
Substrate
n/a
Meas. Tech.
ChEMBL_144468 (CHEMBL755533)
Ki
5.4±n/a nM
Citation
 David, C; Bischoff, L; Meudal, H; Mothé, A; De Mota, N; DaNascimento, S; Llorens-Cortes, C; Fournié-Zaluski, MC; Roques, BP Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem 42:5197-211 (2000) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85570.75
Organism:
Oryctolagus cuniculus (rabbit)
Description:
NEP was purified to homogeneity from rabbit kidney.
Residue:
750
Sequence:
MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGTSWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILTKYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAAIVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
  
Inhibitor
Name:
BDBM50083382
Synonyms:
1-{[1-(1,2-Dicarboxy-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-mercapto-methyl}-3-phosphono-propyl-ammonium | CHEMBL356858
Type:
Small organic molecule
Emp. Form.:
C15H28N3O9PS
Mol. Mass.:
457.436
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@H](S)[C@H]([NH3+])CCP(O)([O-])=O)C(=O)N[C@@H](CC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: