Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50091608
Substrate
n/a
Meas. Tech.
ChEMBL_159325 (CHEMBL769378)
IC50
0.19±n/a nM
Citation
Dorsey, BD; McDonough, C; McDaniel, SL; Levin, RB; Newton, CL; Hoffman, JM; Darke, PL; Zugay-Murphy, JA; Emini, EA; Schleif, WA; Olsen, DB; Stahlhut, MW; Rutkowski, CA; Kuo, LC; Lin, JH; Chen, IW; Michelson, SR; Holloway, MK; Huff, JR; Vacca, JP Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem 43:3386-99 (2000) [PubMed] Article
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM50091608
Synonyms:
1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(6-methyl-furo[3,2-c]pyridin-2-ylmethyl)-piperazine-2-carboxylic acid tert-butylamide | CHEMBL325013
Type:
Small organic molecule
Emp. Form.:
C39H49N5O5
Mol. Mass.:
667.8369
SMILES:
Cc1cc2oc(CN3CCN(C[C@@H](O)C[C@@H](Cc4ccccc4)C(=O)NC4[C@H](O)Cc5ccccc45)[C@@H](C3)C(=O)NC(C)(C)C)cc2cn1