Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50094828
Substrate
n/a
Meas. Tech.
ChEMBL_45081 (CHEMBL657152)
Ki
2±n/a nM
Citation
 Casini, A; Scozzafava, A; Mincione, F; Menabuoni, L; Ilies, MA; Supuran, CT Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. J Med Chem 43:4884-92 (2000) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50094828
Synonyms:
3-Hydroxy-3-phenyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | CHEMBL144946
Type:
Small organic molecule
Emp. Form.:
C16H17N3O5S2
Mol. Mass.:
395.453
SMILES:
NS(=O)(=O)c1ccc(NC(=S)NC(C(O)c2ccccc2)C(O)=O)cc1
Structure:
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