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Reaction Details
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TargetChymase
LigandBDBM50098853
Substrate/Competitorn/a
Meas. Tech.ChEMBL_217038
Ki 1.12±n/a nM
Citation Akahoshi, FAshimori, ASakashita, HYoshimura, TImada, TNakajima, MMitsutomi, NKuwahara, SOhtsuka, TFukaya, CMiyazaki, MNakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase. J Med Chem44:1286-96 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM50098853
NameBDBM50098853
Synonyms:2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester | CHEMBL26285
TypeSmall organic molecule
Emp. Form.C31H27N5O7
Mol. Mass.581.5754
SMILESCOC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(OC)c1
Structure
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n/a