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Reaction Details
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TargetChymase
LigandBDBM50098855
Substrate/Competitorn/a
Meas. Tech.ChEMBL_197663
Ki 183±n/a nM
Citation Akahoshi, FAshimori, ASakashita, HYoshimura, TImada, TNakajima, MMitsutomi, NKuwahara, SOhtsuka, TFukaya, CMiyazaki, MNakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase. J Med Chem44:1286-96 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM50098855
NameBDBM50098855
Synonyms:CHEMBL23870 | N-[2-(5-Amino-benzooxazol-2-yl)-1-benzyl-2-oxo-ethyl]-2-[5-amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetamide
TypeSmall organic molecule
Emp. Form.C28H23FN6O4
Mol. Mass.526.5184
SMILESNc1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccc(F)cc1
Structure
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n/a