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TargetChymotrypsin
LigandBDBM50098882
Substrate/Competitorn/a
Meas. Tech.ChEMBL_49619
Ki 12.6±n/a nM
Citation Akahoshi, FAshimori, ASakashita, HYoshimura, TEda, MImada, TNakajima, MMitsutomi, NKuwahara, SOhtsuka, TFukaya, CMiyazaki, MNakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. J Med Chem44:1297-304 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chymotrypsin
Name:Chymotrypsin C
Synonyms:Caldecrin | Chymotrypsin C | Chymotrypsin-C
Type:Enzyme
Mol. Mass.:29487.98
Organism:Homo sapiens (Human)
Description:Q99895
Residue:268
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG
GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRN
DIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPV
VDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSR
RGCNTRKKPVVYTRVSAYIDWINEKMQL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50098882
NameBDBM50098882
Synonyms:4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid amide | CHEMBL26494
TypeSmall organic molecule
Emp. Form.C24H23F2N5O4
Mol. Mass.483.4673
SMILESCc1cccc(c1)-c1ncc(N)c(=O)n1CC(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(N)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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