Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50113230
Substrate
n/a
Meas. Tech.
ChEMBL_89812 (CHEMBL697550)
IC50
12±n/a nM
Citation
 Dhar, TGShen, ZGuo, JLiu, CWatterson, SHGu, HHPitts, WJFleener, CARouleau, KASherbina, NZMcIntyre, KWShuster, DJWitmer, MRTredup, JAChen, BCZhao, RBednarz, MSCheney, DLMacMaster, JFMiller, LMBerry, KKHarper, TWBarrish, JCHollenbaugh, DLIwanowicz, EJ Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. J Med Chem 45:2127-30 (2002) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50113230
Synonyms:
BMS-337197 | CHEMBL64830 | N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phenylamino)-oxazol-5-yl]-phenyl}-N-methyl-2-morpholin-4-yl-acetamide
Type:
Small organic molecule
Emp. Form.:
C26H27N5O5
Mol. Mass.:
489.5231
SMILES:
COc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CN2CCOCC2)ccc1-c1cnco1
Structure:
Search PDB for entries with ligand similarity: