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Target
Vesicular glutamate transporter 3
Ligand
BDBM50081123
Substrate
n/a
Meas. Tech.
ChEMBL_213569 (CHEMBL874091)
Ki
204000±n/a nM
Citation
 Carrigan, CN; Bartlett, RD; Esslinger, CS; Cybulski, KA; Tongcharoensirikul, P; Bridges, RJ; Thompson, CM Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport. J Med Chem 45:2260-76 (2002) [PubMed]  Article 
Target
Name:
Vesicular glutamate transporter 3
Synonyms:
Slc17a8 | VGLU3_RAT | Vglut3
Type:
PROTEIN
Mol. Mass.:
64750.88
Organism:
Rattus norvegicus
Description:
ChEMBL_213568
Residue:
588
Sequence:
MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPLSYQNEEDFSETS
  
Inhibitor
Name:
BDBM50081123
Synonyms:
6-Benzyloxy-quinoline-2,4-dicarboxylic acid | CHEMBL73304
Type:
Small organic molecule
Emp. Form.:
C18H13NO5
Mol. Mass.:
323.2995
SMILES:
OC(=O)c1cc(C(O)=O)c2cc(OCc3ccccc3)ccc2n1
Structure:
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