Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50116468
Substrate
n/a
Meas. Tech.
ChEMBL_32152 (CHEMBL646279)
Ki
11900±n/a nM
Citation
 Müller, CE; Thorand, M; Qurishi, R; Diekmann, M; Jacobson, KA; Padgett, WL; Daly, JW Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem 45:3440-50 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50116468
Synonyms:
2-Chloro-1,4-dimethyl-4,6,7,8-tetrahydro-1H-1,3,4,5a,9-pentaaza-cyclopenta[a]naphthalen-5-one | CHEMBL323615
Type:
Small organic molecule
Emp. Form.:
C10H12ClN5O
Mol. Mass.:
253.688
SMILES:
CN1c2nc(Cl)n(C)c2C2=NCCCN2C1=O |t:10|
Structure:
Search PDB for entries with ligand similarity: