Target
Histamine H1 receptor
Ligand
BDBM35254
Substrate
n/a
Meas. Tech.
ChEMBL_84714 (CHEMBL884684)
Ki
0.3±n/a nM
Citation
 Campiani, GButini, SGemma, SNacci, VFattorusso, CCatalanotti, BGiorgi, GCagnotto, AGoegan, MMennini, TMinetti, PDi Cesare, MAMastroianni, DScafetta, NGalletti, BStasi, MACastorina, MPacifici, LGhirardi, OTinti, OCarminati, P Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. J Med Chem 45:344-59 (2002) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM35254
Synonyms:
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine | CHEMBL715 | Olansek | US8802672, Olanzapine | Zyprexa | olanzapine
Type:
Small organic molecule
Emp. Form.:
C17H20N4S
Mol. Mass.:
312.432
SMILES:
CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12 |t:8|
Structure:
Search PDB for entries with ligand similarity: