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Target
Interstitial collagenase
Ligand
BDBM50109616
Substrate
n/a
Meas. Tech.
ChEMBL_106139 (CHEMBL718686)
Ki
7.8±n/a nM
Citation
 Sawa, M; Kiyoi, T; Kurokawa, K; Kumihara, H; Yamamoto, M; Miyasaka, T; Ito, Y; Hirayama, R; Inoue, T; Kirii, Y; Nishiwaki, E; Ohmoto, H; Maeda, Y; Ishibushi, E; Inoue, Y; Yoshino, K; Kondo, H New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. J Med Chem 45:919-29 (2002) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50109616
Synonyms:
(7-Hydroxycarbamoyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester | CHEMBL177072
Type:
Small organic molecule
Emp. Form.:
C17H21N4O5P
Mol. Mass.:
392.3462
SMILES:
CCOP(=O)(N1Cc2nccnc2CC1C(=O)NO)c1ccc(OC)cc1
Structure:
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