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Target
Purine nucleoside phosphorylase
Ligand
BDBM50135919
Substrate
n/a
Meas. Tech.
ChEMBL_162006 (CHEMBL764177)
Ki
2±n/a nM
Citation
 Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. J Med Chem 46:5271-6 (2003) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50135919
Synonyms:
3-(3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl)-1H-pyrazolo[4,3-d]pyrimidin-7-ol | CHEMBL357062
Type:
Small organic molecule
Emp. Form.:
C11H15N5O3
Mol. Mass.:
265.2685
SMILES:
OC[C@H]1CN(Cc2[nH]nc3c2nc[nH]c3=O)CC1O
Structure:
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