Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 3
Ligand
BDBM50155597
Substrate
n/a
Meas. Tech.
ChEMBL_305864 (CHEMBL831908)
IC50
3900±n/a nM
Citation
 Contour-Galcéra, MO; Lavergne, O; Brezak, MC; Ducommun, B; Prévost, G Synthesis of small molecule CDC25 phosphatases inhibitors. Bioorg Med Chem Lett 14:5809-12 (2004) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 3
Synonyms:
CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN
Type:
Substrate
Mol. Mass.:
53366.11
Organism:
Homo sapiens (Human)
Description:
P30307
Residue:
473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
  
Inhibitor
Name:
BDBM50155597
Synonyms:
4-Dimethylamino-2-{[2-(4-nitro-phenyl)-ethylamino]-methyl}-phenol | CHEMBL186631
Type:
Small organic molecule
Emp. Form.:
C17H21N3O3
Mol. Mass.:
315.3669
SMILES:
CN(C)c1ccc(O)c(CNCCc2ccc(cc2)[N+]([O-])=O)c1
Structure:
Search PDB for entries with ligand similarity: