Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50167871
Substrate
n/a
Meas. Tech.
ChEMBL_306461 (CHEMBL829538)
IC50
0.185±n/a nM
Citation
 Kamei, K; Maeda, N; Katsuragi-Ogino, R; Koyama, M; Nakajima, M; Tatsuoka, T; Ohno, T; Inoue, T New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects. Bioorg Med Chem Lett 15:2990-3 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50167871
Synonyms:
3-Chloro-4-{4-[5-(4-methyl-pyrimidin-2-yl)-3,4-dihydro-2H-pyridin-1-yl]-butyl}-4H-benzo[f][1,4]oxazepin-5-one; Compound with fumarate
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O2
Mol. Mass.:
424.923
SMILES:
Cc1ccnc(n1)C1=CN(CCCCN2C(Cl)=COc3ccccc3C2=O)CCC1 |c:17,t:8|
Structure:
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