Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50167873
Substrate
n/a
Meas. Tech.
ChEMBL_306461 (CHEMBL829538)
IC50
2650±n/a nM
Citation
 Kamei, KMaeda, NKatsuragi-Ogino, RKoyama, MNakajima, MTatsuoka, TOhno, TInoue, T New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects. Bioorg Med Chem Lett 15:2990-3 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50167873
Synonyms:
3-Chloro-4-[4-(4-hydroxy-4-pyrimidin-2-yl-piperidin-1-yl)-butyl]-4H-benzo[f][1,4]oxazepin-5-one; hydrochloride | CHEMBL535155
Type:
Small organic molecule
Emp. Form.:
C22H25ClN4O3
Mol. Mass.:
428.912
SMILES:
OC1(CCN(CCCCN2C(Cl)=COc3ccccc3C2=O)CC1)c1ncccn1 |c:11|
Structure:
Search PDB for entries with ligand similarity: