Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50171015
Substrate
n/a
Meas. Tech.
ChEMBL_302944 (CHEMBL841779)
Ki
13±n/a nM
Citation
 Mincione, F; Starnotti, M; Masini, E; Bacciottini, L; Scrivanti, C; Casini, A; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett 15:3821-7 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50171015
Synonyms:
CHEMBL182135 | N-[4-(aminosulfonyl)phenyl]-2-(2-morpholin-4-ylethyl)hydrazinecarbothioamide
Type:
Small organic molecule
Emp. Form.:
C13H21N5O3S2
Mol. Mass.:
359.468
SMILES:
NS(=O)(=O)c1ccc(NC(=S)NNCCN2CCOCC2)cc1
Structure:
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